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Changes to This Summary (10/17/2008)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Introduction 1
Cited Lindor et al. as reference 9 2.
Major Genes 3
Added text 4 to state that one in 400 to 800 individuals in the general population may carry a pathogenic mutation in BRCA1 and BRCA2 (cited Ford et al. and Whittemore et al. as references 21 and 22, respectively).
Added text 5 about two large U.S. population-based studies of breast cancer patients that examined the prevalence of BRCA1 and BRCA2 mutations in various ethnic groups (cited John et al. and Malone et al. as references 38 and 40, respectively).
Added text 6 about the role of BRCA1 and BRCA2 in sporadic cancer (cited Futreal et al. as reference 121, Lancaster et al. as reference 122, Miki et al. as reference 123, Teng et al. as reference 124, Thompson et al. as reference 126, Dobrovic et al. as reference 127, Cleton-Jansen et al. as reference 128, Hamann et al. as reference 129, Birgisdottir et al. as reference 130, Turner et al. as reference 131, Rakha et al. as reference 132, Hilton et al. as reference 133, Quinn et al. as reference 134, Geisler et al. as reference 135, and Farmer et al. as reference 136.
Interventions 7
Added text 8 about a study of 171 women that found that ultrasound screening appears to have a limited benefit in combination with MRI (cited Lehman et al. as reference 29).
Psychosocial Issues in Inherited Breast Cancer Syndromes 9
Cited Mikkelsen et al. as reference 35 10.
Added text 11 about several studies that have explored communication of BRCA test results to at-risk children (cited Hughes et al. as reference 125, cited Tercyak et al. as reference 126, McGivern et al. as reference 128, and 2007 Tercyak et al. as reference 129).
Added Decision aids for persons considering risk management options for hereditary breast and ovarian cancer 12 as a new subsection.
Added tables 6 and 7 to the Uptake of cancer risk management options 13 section. |
