National Cancer Institute National Cancer Institute
U.S. National Institutes of Health National Cancer Institute
NCI Home Cancer Topics Clinical Trials Cancer Statistics Research & Funding News About NCI
Genetics of Prostate Cancer (PDQ®)
Health Professional VersionLast Modified: 12/19/2008
Table 5. Summary of Cross-Sectional Studies of Anticipated Interest in Prostate Cancer Susceptibility Genetic Testing

Study Population  Sample Size  Percent Expressing Interest in Genetic Testing  Other Findings 
Prostate screening clinic participants [17] 342 men aged 40 to 97 years 89% 28% did not demonstrate an understanding of the concept of inherited predisposition to cancer
General population; 9% with positive family history [8] 12 focus groups with a total of 90 men aged 18 to 70 years All focus groups
African American men [18] 320 men aged 21 to 98 years 87% Most participants could not distinguish between genetic susceptibility testing and a prostate-specific antigen blood test
Men with and without first-degree male relatives with prostate cancer [9] 126 men older than 40 years; mean age 52.6 years 24% definitely; 50% probably
Swedish men with a FDR with prostate cancer [3] 110 men aged 40 to 72 years 76% definitely; 18% probably 89% definitely or probably wanted their sons to undergo genetic testing
Sons of Swedish men with prostate cancer [10] 101 men aged 21 to 65 years 90%; 100% of sons with 2 to 3 family members affected with prostate cancer 60% expressed worry about having an increased risk for prostate cancer
Healthy outpatient males with no history of prostate cancer [19] 400 men aged 40 to 69 years 82%
Healthy African American males with no history of prostate cancer [20] 413 African American men aged 40 to 70 years 87% Belief in the efficacy of and intention to undergo prostate cancer screening was associated with testing interest

References

  1. Bratt O, Damber JE, Emanuelsson M, et al.: Risk perception, screening practice and interest in genetic testing among unaffected men in families with hereditary prostate cancer. Eur J Cancer 36 (2): 235-41, 2000.  [PUBMED Abstract]

  2. Doukas DJ, Fetters MD, Coyne JC, et al.: How men view genetic testing for prostate cancer risk: findings from focus groups. Clin Genet 58 (3): 169-76, 2000.  [PUBMED Abstract]

  3. Diefenbach MA, Schnoll RA, Miller SM, et al.: Genetic testing for prostate cancer. Willingness and predictors of interest. Cancer Pract 8 (2): 82-6, 2000 Mar-Apr.  [PUBMED Abstract]

  4. Bratt O, Kristoffersson U, Lundgren R, et al.: Sons of men with prostate cancer: their attitudes regarding possible inheritance of prostate cancer, screening, and genetic testing. Urology 50 (3): 360-5, 1997.  [PUBMED Abstract]

  5. Miesfeldt S, Jones SM, Cohn W, et al.: Men's attitudes regarding genetic testing for hereditary prostate cancer risk. Urology 55 (1): 46-50, 2000.  [PUBMED Abstract]

  6. Weinrich S, Royal C, Pettaway CA, et al.: Interest in genetic prostate cancer susceptibility testing among African American men. Cancer Nurs 25 (1): 28-34, 2002.  [PUBMED Abstract]

  7. Doukas DJ, Li Y: Men's values-based factors on prostate cancer risk genetic testing: a telephone survey. BMC Med Genet 5: 28, 2004.  [PUBMED Abstract]

  8. Myers RE, Hyslop T, Jennings-Dozier K, et al.: Intention to be tested for prostate cancer risk among African-American men. Cancer Epidemiol Biomarkers Prev 9 (12): 1323-8, 2000.  [PUBMED Abstract]


A Service of the National Cancer Institute
Department of Health and Human Services National Institutes of Health USA.gov